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 Bioprocessing Check Valves

Nordson Medical’s bioprocessing check valves are engineered to regulate the directional flow of fluids and come in diverse configurations tailored to specific needs. Single-configuration check valves prevent backflow in one direction. Double-configuration check valves manage bidirectional flow.  

These valves ensure precise flow management and accommodate higher flow rates.

They feature low cracking pressures, seamless priming, compatibility with multiple sterilization methods and reduced contamination risks.

They meet stringent biocompatibility and performance requirements, making them ideal for fluid management in bioprocesses.

Download the datasheet bioprocessing Check Valves

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 Typical Applications

  • Media and buffer transfer lines
  • Filtration and filling systems
  • Pumping applications
  • Sampling lines
  • Cell culture fluid management

Features

  • Available in single‑configuration and double‑configuration formats
  • Materials meet USP Class VI & ISO 10993 criteria
  • Air entrapment readily alleviated during priming
  • Operate in any spatial orientation
  • Low cracking pressures
  • Barbed check valves with from 1/8”(3.2 mm) to 1/4″ (6.4mm) single barb ends
  • Bi-directional check valves
  • Custom configurations

Benefits

  • Reliable backflow prevention: ensure consistent directional flow and eliminate reverse flow risks.
  • Improved system efficiency: low opening pressures supporting high flow rates, allowing smooth priming and reducing air entrapment during setup.
  • Flexible orientation: all valves operate in any spatial orientation, simplifying device layout and tubing architecture.
  • Sterilization compatibility: depending on the reference, gamma irradiation or compatible with EtO sterilization, ensuring safe integration into sterile workflows.
  • Configurable for multiple applications: available with luers, barbs and designs to match various bioprocessing systems.
  • Contamination control: seamless priming and normally closed pathways reduce contamination risk for your bioprocesses.

FAQ

Bioprocessing Check Valves

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Are Nordson Medical Check valves compatible with sterilization methods such as gamma?

Nordson Medical Check valves are compatible with sterilization methods such as gamma for most of the references. The housings and silicone diaphragms are gamma‑stable, making them suitable for sterile bioprocessing environments.

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Can Nordson Medical check valves be integrated into single-use assemblies?

Absolutely. Nordson Medical check valves are commonly integrated into Aseptic Group custom single-use assemblies, enabling plug-and-play solutions that reduce contamination risk and improve operational efficiency.

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Can Nordson Medical check valves operate in any orientation?

Yes. All Nordson Medical check valves are engineered to operate in any spatial orientation, ensuring design flexibility and reliable performance during use.

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How do I select the right check valve for my application?

Key selection criteria include:

  • Required cracking pressure
  • Flow rate and pressure conditions
  • Chemical compatibility
  • Sterilisation method
  • Integration requirements (e.g., tubing size, connectors)

Aseptic Group experts can help you. Please consult us.

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What are Bioprocessing check valves used for?

Single-Use Bioprocessing check valves are used to prevent backflow and preserve product integrity.

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What are the key benefits of Nordson Medical check valves?

Nordson Medical check valves offer:

  • Low cracking pressure for precise flow control
  • Reliable sealing to prevent backflow
  • Compatibility with multiple sterilization methods
  • Biocompatible, high-purity materials
  • Integration into single-use assemblies

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What is a bioprocessing Check Valves?

A check valve is a component that regulates the directional flow of fluids and comes in diverse configurations tailored to specific needs. 

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What is a bioprocessing Check Valves?

A check valve is a single-use fluid control component that regulates the directional flow of fluid. It is used to protect critical processes from contamination and ensure controlled fluid transfer in biopharmaceutical applications.

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What is the difference between single‑configuration and double‑configuration bioprocessing check valves?

A Single‑configuration check valves prevents backflow in one direction and is normally closed, requiring positive pressure to open.

A double‑configuration check valves allows bidirectional flow by directing fluid to multiple outlets sequentially.

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What makes Nordson Medical check valves suitable for bioprocessapplications?

Nordson Medical check valves use USP Class VI–compliant materials, feature low cracking pressures, and are designed to minimize contamination and ensure consistent directional flow.

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What materials are used in Nordson Medical check valves?

Nordson Medical check valves are typically made from high-purity polymers such as polycarbonate, polypropylene, silicone, or other biocompatible elastomers, ensuring compliance with biopharma regulatory requirements.

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Why are non-return valves important in biopharmaceutical applications?

Non-return valves help preserve product integrity by preventing backflow, cross-contamination and unintentional mixing of fluids. They are essential for protecting upstream and downstream processes, particularly in sterile and aseptic environments.

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